Christian Heinen studied Biology at the universities Bochum (Germany), Lund (Sweden) and Göttingen (Germany) with main focus on Biochemistry, Human Genetics and Organic Chemistry. His diploma thesis research was carried out at the Center of Biochemistry and Molecular Cell Biology at the Georg-August University of Göttingen where he worked on the analysis of mRNA secondary structures. After finishing his degree in 2004, he continued working on this project for a few months, before he moved to Stockholm (Sweden) in early 2005, to join the research group of Nico Dantuma at the Department of Cell and Molecular Biology of the Karolinska Institute as a PhD student. In his research project, he is focusing on the ubiquitin-proteasome system and the mechanism of how proteins evade degradation. In his life after work, he enjoys music, football and running.
Christian defended on August 27, 2010 his thesis entitled: 'To Degrade or not to Degrade: Protein Handling by the Proteasome'. In October 2010, Christian joined the laboratory of Dr. Vlad Denic at Harvard University as a postdoctoral fellow. He received a postdoctoral fellowship of the Wenner-Gren Foundation.
He contributed to the following publications:
Heinen, C., K. Ács, D. Hoogstraten and N.P. Dantuma. 2011. C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation. Nat. Commun. 2, 191. (Open Access).
Heinen, C., T.P. Garner, J. Long, C. Böttcher, S.H. Ralston, J.R. Cavey, M.S. Searle, R. Layfield and N. P. Dantuma*. 2010. Mutant p62/SQSTM1 UBA domains linked to Paget’s disease of bone differ in their abilities to function as stabilization signals. FEBS Lett. 584:1585-1590.
Dantuma, N.P.*, C. Heinen, D. Hoogstraten. 2009. The ubiquitin receptor Rad23: At the crossroads of nucleotide excision repair and proteasomal degradation. DNA Repair (Amst). 8:449-460. (review)
Verhoef, L.G.G.C., C. Heinen, A. Selivanova,To be continued
